Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR

Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones. Activation of PXR has the potential to initiate adverse effects, a...

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Detalles Bibliográficos
Autores principales: Ekins, Sean, Kortagere, Sandhya, Iyer, Manisha, Reschly, Erica J., Lill, Markus A., Redinbo, Matthew R., Krasowski, Matthew D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781111/
https://www.ncbi.nlm.nih.gov/pubmed/20011107
http://dx.doi.org/10.1371/journal.pcbi.1000594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781111/
https://www.ncbi.nlm.nih.gov/pubmed/20011107
http://dx.doi.org/10.1371/journal.pcbi.1000594

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