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The effect of curcumin (turmeric) on Alzheimer's disease: An overview
This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cys...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ https://www.ncbi.nlm.nih.gov/pubmed/19966973 http://dx.doi.org/10.4103/0972-2327.40220 |
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author | Mishra, Shrikant Palanivelu, Kalpana |
author_facet | Mishra, Shrikant Palanivelu, Kalpana |
author_sort | Mishra, Shrikant |
collection | PubMed |
description | This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology. |
format | Text |
id | pubmed-2781139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-27811392009-12-04 The effect of curcumin (turmeric) on Alzheimer's disease: An overview Mishra, Shrikant Palanivelu, Kalpana Ann Indian Acad Neurol Review Article This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology. Medknow Publications 2008 /pmc/articles/PMC2781139/ /pubmed/19966973 http://dx.doi.org/10.4103/0972-2327.40220 Text en © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mishra, Shrikant Palanivelu, Kalpana The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title_full | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title_fullStr | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title_full_unstemmed | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title_short | The effect of curcumin (turmeric) on Alzheimer's disease: An overview |
title_sort | effect of curcumin (turmeric) on alzheimer's disease: an overview |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ https://www.ncbi.nlm.nih.gov/pubmed/19966973 http://dx.doi.org/10.4103/0972-2327.40220 |
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