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The effect of curcumin (turmeric) on Alzheimer's disease: An overview

This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cys...

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Detalles Bibliográficos
Autores principales: Mishra, Shrikant, Palanivelu, Kalpana
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/
https://www.ncbi.nlm.nih.gov/pubmed/19966973
http://dx.doi.org/10.4103/0972-2327.40220
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author Mishra, Shrikant
Palanivelu, Kalpana
author_facet Mishra, Shrikant
Palanivelu, Kalpana
author_sort Mishra, Shrikant
collection PubMed
description This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology.
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spelling pubmed-27811392009-12-04 The effect of curcumin (turmeric) on Alzheimer's disease: An overview Mishra, Shrikant Palanivelu, Kalpana Ann Indian Acad Neurol Review Article This paper discusses the effects of curcumin on patients with Alzheimer's disease (AD). Curcumin (Turmeric), an ancient Indian herb used in curry powder, has been extensively studied in modern medicine and Indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. It has been used in various types of treatments for dementia and traumatic brain injury. Curcumin also has a potential role in the prevention and treatment of AD. Curcumin as an antioxidant, anti-inflammatory and lipophilic action improves the cognitive functions in patients with AD. A growing body of evidence indicates that oxidative stress, free radicals, beta amyloid, cerebral deregulation caused by bio-metal toxicity and abnormal inflammatory reactions contribute to the key event in Alzheimer's disease pathology. Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. This paper reviews the various mechanisms of actions of curcumin in AD and pathology. Medknow Publications 2008 /pmc/articles/PMC2781139/ /pubmed/19966973 http://dx.doi.org/10.4103/0972-2327.40220 Text en © Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mishra, Shrikant
Palanivelu, Kalpana
The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title_full The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title_fullStr The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title_full_unstemmed The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title_short The effect of curcumin (turmeric) on Alzheimer's disease: An overview
title_sort effect of curcumin (turmeric) on alzheimer's disease: an overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/
https://www.ncbi.nlm.nih.gov/pubmed/19966973
http://dx.doi.org/10.4103/0972-2327.40220
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