Global MYCN Transcription Factor Binding Analysis in Neuroblastoma Reveals Association with Distinct E-Box Motifs and Regions of DNA Hypermethylation

BACKGROUND: Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor clinical outcome in this disease is genomic amplification of MYCN, a member of a family of o...

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Detalles Bibliográficos
Autores principales: Murphy, Derek M., Buckley, Patrick G., Bryan, Kenneth, Das, Sudipto, Alcock, Leah, Foley, Niamh H., Prenter, Suzanne, Bray, Isabella, Watters, Karen M., Higgins, Desmond, Stallings, Raymond L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781550/
https://www.ncbi.nlm.nih.gov/pubmed/19997598
http://dx.doi.org/10.1371/journal.pone.0008154

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