Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains

Mutations in polycystin-1 (PC1) can cause autosomal dominant polycystic kidney disease, which is a leading cause of renal failure. The available evidence suggests that PC1 acts as a mechanosensor, receiving signals from the primary cilia, neighboring cells, and extracellular matrix. PC1 is a large m...

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Detalles Bibliográficos
Autores principales: Ma, Liang, Xu, Meixiang, Forman, Julia R., Clarke, Jane, Oberhauser, Andres F.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781709/
https://www.ncbi.nlm.nih.gov/pubmed/19759016
http://dx.doi.org/10.1074/jbc.M109.021832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781709/
https://www.ncbi.nlm.nih.gov/pubmed/19759016
http://dx.doi.org/10.1074/jbc.M109.021832

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