Loss of the Histone Pre-mRNA Processing Factor Stem-Loop Binding Protein in Drosophila Causes Genomic Instability and Impaired Cellular Proliferation

BACKGROUND: Metazoan replication-dependent histone mRNAs terminate in a conserved stem-loop structure rather than a polyA tail. Formation of this unique mRNA 3′ end requires Stem-loop Binding Protein (SLBP), which directly binds histone pre-mRNA and stimulates 3′ end processing. The 3′ end stem-loop...

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Detalles Bibliográficos
Autores principales: Salzler, Harmony R., Davidson, Jean M., Montgomery, Nathan D., Duronio, Robert J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781718/
https://www.ncbi.nlm.nih.gov/pubmed/19997601
http://dx.doi.org/10.1371/journal.pone.0008168

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