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Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation
In this paper, we investigate the pharmacokinetics and effect of doxorubicin and cisplatin in vascularized tumors through two-dimensional simulations. We take into account especially vascular and morphological heterogeneity as well as cellular and lesion-level pharmacokinetic determinants like P-gly...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782117/ https://www.ncbi.nlm.nih.gov/pubmed/18781304 http://dx.doi.org/10.1007/s00285-008-0214-y |