Apolipoprotein E-Mimetics Inhibit Neurodegeneration and Restore Cognitive Functions in a Transgenic Drosophila Model of Alzheimer's Disease

BACKGROUND: Mutations of the amyloid precursor protein gene (APP) are found in familial forms of Alzheimer's disease (AD) and some lead to the elevated production of amyloid-β-protein (Aβ). While Aβ has been implicated in the causation of AD, the exact role played by Aβ and its APP precursor ar...

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Detalles Bibliográficos
Autores principales: Sarantseva, Svetlana, Timoshenko, Svetlana, Bolshakova, Olga, Karaseva, Eugenia, Rodin, Dmitry, Schwarzman, Alexander L., Vitek, Michael P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782140/
https://www.ncbi.nlm.nih.gov/pubmed/19997607
http://dx.doi.org/10.1371/journal.pone.0008191

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