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Cutaneous Metastasis of Choriocarcinoma : A Case Report
Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A...
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782171/ https://www.ncbi.nlm.nih.gov/pubmed/16100467 http://dx.doi.org/10.3346/jkms.2005.20.4.683 |
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author | Park, Sang Gun Chang, Jae Yong Kim, Se Hoon Bang, Dongsik |
author_facet | Park, Sang Gun Chang, Jae Yong Kim, Se Hoon Bang, Dongsik |
author_sort | Park, Sang Gun |
collection | PubMed |
description | Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A 52-yr-old female complaining of dyspnea for 2 months, presented with fingertip sized erythematous nodules on the left side of the neck and the right side of the upper back of 1 month duraton. She has suffered from Behçet's disease since 1999. Microscopic examination of a nodule of upper back demonstrated biphasic pattern of cytotrophoblasts and hCG-positive syncytiotrophoblasts, and the typical histologic features of choriocarcinoma. She was referred to the gynecological oncology department. After 17 cycles of combination chemotherapy, the serum hCG level has fallen from 700,000 to under 2.0 mIU/mL and the skin lesions have almost disappeared. However, after 3 months, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed due to elevated serum hCG level (4,447.7 mIU/mL), and she is scheduled to receive post-operative adjuvant chemotherapy. |
format | Text |
id | pubmed-2782171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27821712009-11-25 Cutaneous Metastasis of Choriocarcinoma : A Case Report Park, Sang Gun Chang, Jae Yong Kim, Se Hoon Bang, Dongsik J Korean Med Sci Case Report Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A 52-yr-old female complaining of dyspnea for 2 months, presented with fingertip sized erythematous nodules on the left side of the neck and the right side of the upper back of 1 month duraton. She has suffered from Behçet's disease since 1999. Microscopic examination of a nodule of upper back demonstrated biphasic pattern of cytotrophoblasts and hCG-positive syncytiotrophoblasts, and the typical histologic features of choriocarcinoma. She was referred to the gynecological oncology department. After 17 cycles of combination chemotherapy, the serum hCG level has fallen from 700,000 to under 2.0 mIU/mL and the skin lesions have almost disappeared. However, after 3 months, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed due to elevated serum hCG level (4,447.7 mIU/mL), and she is scheduled to receive post-operative adjuvant chemotherapy. The Korean Academy of Medical Sciences 2005-08 2005-08-31 /pmc/articles/PMC2782171/ /pubmed/16100467 http://dx.doi.org/10.3346/jkms.2005.20.4.683 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Park, Sang Gun Chang, Jae Yong Kim, Se Hoon Bang, Dongsik Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title | Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title_full | Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title_fullStr | Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title_full_unstemmed | Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title_short | Cutaneous Metastasis of Choriocarcinoma : A Case Report |
title_sort | cutaneous metastasis of choriocarcinoma : a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782171/ https://www.ncbi.nlm.nih.gov/pubmed/16100467 http://dx.doi.org/10.3346/jkms.2005.20.4.683 |
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