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Cutaneous Metastasis of Choriocarcinoma : A Case Report

Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A...

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Autores principales: Park, Sang Gun, Chang, Jae Yong, Kim, Se Hoon, Bang, Dongsik
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782171/
https://www.ncbi.nlm.nih.gov/pubmed/16100467
http://dx.doi.org/10.3346/jkms.2005.20.4.683
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author Park, Sang Gun
Chang, Jae Yong
Kim, Se Hoon
Bang, Dongsik
author_facet Park, Sang Gun
Chang, Jae Yong
Kim, Se Hoon
Bang, Dongsik
author_sort Park, Sang Gun
collection PubMed
description Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A 52-yr-old female complaining of dyspnea for 2 months, presented with fingertip sized erythematous nodules on the left side of the neck and the right side of the upper back of 1 month duraton. She has suffered from Behçet's disease since 1999. Microscopic examination of a nodule of upper back demonstrated biphasic pattern of cytotrophoblasts and hCG-positive syncytiotrophoblasts, and the typical histologic features of choriocarcinoma. She was referred to the gynecological oncology department. After 17 cycles of combination chemotherapy, the serum hCG level has fallen from 700,000 to under 2.0 mIU/mL and the skin lesions have almost disappeared. However, after 3 months, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed due to elevated serum hCG level (4,447.7 mIU/mL), and she is scheduled to receive post-operative adjuvant chemotherapy.
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spelling pubmed-27821712009-11-25 Cutaneous Metastasis of Choriocarcinoma : A Case Report Park, Sang Gun Chang, Jae Yong Kim, Se Hoon Bang, Dongsik J Korean Med Sci Case Report Choriocarcinoma is one of the malignant tumors of trophoblastic cells characterized by the secretion of human chorionic gonadotrophin (hCG) (1-3). Cutaneous metastasis is a rare presentation of choriocarcinoma but a poor prognostic sign because it is associated only with widespread disease (3-5). A 52-yr-old female complaining of dyspnea for 2 months, presented with fingertip sized erythematous nodules on the left side of the neck and the right side of the upper back of 1 month duraton. She has suffered from Behçet's disease since 1999. Microscopic examination of a nodule of upper back demonstrated biphasic pattern of cytotrophoblasts and hCG-positive syncytiotrophoblasts, and the typical histologic features of choriocarcinoma. She was referred to the gynecological oncology department. After 17 cycles of combination chemotherapy, the serum hCG level has fallen from 700,000 to under 2.0 mIU/mL and the skin lesions have almost disappeared. However, after 3 months, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed due to elevated serum hCG level (4,447.7 mIU/mL), and she is scheduled to receive post-operative adjuvant chemotherapy. The Korean Academy of Medical Sciences 2005-08 2005-08-31 /pmc/articles/PMC2782171/ /pubmed/16100467 http://dx.doi.org/10.3346/jkms.2005.20.4.683 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Park, Sang Gun
Chang, Jae Yong
Kim, Se Hoon
Bang, Dongsik
Cutaneous Metastasis of Choriocarcinoma : A Case Report
title Cutaneous Metastasis of Choriocarcinoma : A Case Report
title_full Cutaneous Metastasis of Choriocarcinoma : A Case Report
title_fullStr Cutaneous Metastasis of Choriocarcinoma : A Case Report
title_full_unstemmed Cutaneous Metastasis of Choriocarcinoma : A Case Report
title_short Cutaneous Metastasis of Choriocarcinoma : A Case Report
title_sort cutaneous metastasis of choriocarcinoma : a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782171/
https://www.ncbi.nlm.nih.gov/pubmed/16100467
http://dx.doi.org/10.3346/jkms.2005.20.4.683
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