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Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

Integrins have emerged as key sensory molecules that translate chemical and physical cues from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior. Integrins function by clustering into adhesion plaques, but the molecular mechanisms that drive integrin clustering in r...

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Detalles Bibliográficos
Autores principales: Paszek, Matthew J., Boettiger, David, Weaver, Valerie M., Hammer, Daniel A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782178/
https://www.ncbi.nlm.nih.gov/pubmed/20011123
http://dx.doi.org/10.1371/journal.pcbi.1000604