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The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults

The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,90...

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Autores principales: Shin, Min-Ho, Kim, Hee Nam, Cui, Lian-Hua, Kweon, Sun-Seog, Park, Kyeong-Soo, Heo, Heon, Nam, Hae-Sung, Jeong, Seul-Ki, Chung, Eun-Kyung, Choi, Jin-Su
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782187/
https://www.ncbi.nlm.nih.gov/pubmed/15953853
http://dx.doi.org/10.3346/jkms.2005.20.3.361
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author Shin, Min-Ho
Kim, Hee Nam
Cui, Lian-Hua
Kweon, Sun-Seog
Park, Kyeong-Soo
Heo, Heon
Nam, Hae-Sung
Jeong, Seul-Ki
Chung, Eun-Kyung
Choi, Jin-Su
author_facet Shin, Min-Ho
Kim, Hee Nam
Cui, Lian-Hua
Kweon, Sun-Seog
Park, Kyeong-Soo
Heo, Heon
Nam, Hae-Sung
Jeong, Seul-Ki
Chung, Eun-Kyung
Choi, Jin-Su
author_sort Shin, Min-Ho
collection PubMed
description The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 (E2) allele had significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 (E3) or APOE*E4 (E4) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels.
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spelling pubmed-27821872009-11-30 The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults Shin, Min-Ho Kim, Hee Nam Cui, Lian-Hua Kweon, Sun-Seog Park, Kyeong-Soo Heo, Heon Nam, Hae-Sung Jeong, Seul-Ki Chung, Eun-Kyung Choi, Jin-Su J Korean Med Sci Original Article The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 (E2) allele had significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 (E3) or APOE*E4 (E4) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels. The Korean Academy of Medical Sciences 2005-06 2005-06-30 /pmc/articles/PMC2782187/ /pubmed/15953853 http://dx.doi.org/10.3346/jkms.2005.20.3.361 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Min-Ho
Kim, Hee Nam
Cui, Lian-Hua
Kweon, Sun-Seog
Park, Kyeong-Soo
Heo, Heon
Nam, Hae-Sung
Jeong, Seul-Ki
Chung, Eun-Kyung
Choi, Jin-Su
The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title_full The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title_fullStr The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title_full_unstemmed The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title_short The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
title_sort effect of apolipoprotein e polymorphism on lipid levels in korean adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782187/
https://www.ncbi.nlm.nih.gov/pubmed/15953853
http://dx.doi.org/10.3346/jkms.2005.20.3.361
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