Cargando…
The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults
The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,90...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782187/ https://www.ncbi.nlm.nih.gov/pubmed/15953853 http://dx.doi.org/10.3346/jkms.2005.20.3.361 |
_version_ | 1782174620150923264 |
---|---|
author | Shin, Min-Ho Kim, Hee Nam Cui, Lian-Hua Kweon, Sun-Seog Park, Kyeong-Soo Heo, Heon Nam, Hae-Sung Jeong, Seul-Ki Chung, Eun-Kyung Choi, Jin-Su |
author_facet | Shin, Min-Ho Kim, Hee Nam Cui, Lian-Hua Kweon, Sun-Seog Park, Kyeong-Soo Heo, Heon Nam, Hae-Sung Jeong, Seul-Ki Chung, Eun-Kyung Choi, Jin-Su |
author_sort | Shin, Min-Ho |
collection | PubMed |
description | The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 (E2) allele had significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 (E3) or APOE*E4 (E4) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels. |
format | Text |
id | pubmed-2782187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27821872009-11-30 The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults Shin, Min-Ho Kim, Hee Nam Cui, Lian-Hua Kweon, Sun-Seog Park, Kyeong-Soo Heo, Heon Nam, Hae-Sung Jeong, Seul-Ki Chung, Eun-Kyung Choi, Jin-Su J Korean Med Sci Original Article The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 (E2) allele had significantly lower total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 (E3) or APOE*E4 (E4) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels. The Korean Academy of Medical Sciences 2005-06 2005-06-30 /pmc/articles/PMC2782187/ /pubmed/15953853 http://dx.doi.org/10.3346/jkms.2005.20.3.361 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shin, Min-Ho Kim, Hee Nam Cui, Lian-Hua Kweon, Sun-Seog Park, Kyeong-Soo Heo, Heon Nam, Hae-Sung Jeong, Seul-Ki Chung, Eun-Kyung Choi, Jin-Su The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title | The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title_full | The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title_fullStr | The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title_full_unstemmed | The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title_short | The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults |
title_sort | effect of apolipoprotein e polymorphism on lipid levels in korean adults |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782187/ https://www.ncbi.nlm.nih.gov/pubmed/15953853 http://dx.doi.org/10.3346/jkms.2005.20.3.361 |
work_keys_str_mv | AT shinminho theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT kimheenam theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT cuilianhua theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT kweonsunseog theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT parkkyeongsoo theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT heoheon theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT namhaesung theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT jeongseulki theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT chungeunkyung theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT choijinsu theeffectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT shinminho effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT kimheenam effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT cuilianhua effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT kweonsunseog effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT parkkyeongsoo effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT heoheon effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT namhaesung effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT jeongseulki effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT chungeunkyung effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults AT choijinsu effectofapolipoproteinepolymorphismonlipidlevelsinkoreanadults |