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Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans
1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)(2)D(3) exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five K...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782210/ https://www.ncbi.nlm.nih.gov/pubmed/15953876 http://dx.doi.org/10.3346/jkms.2005.20.3.495 |
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author | Kim, Joong-Seok Kim, Yeong-In Song, Christopher Yoon, Injin Park, Jeong-Wook Choi, Young-Bin Kim, Hee-Tae Lee, Kwang-Soo |
author_facet | Kim, Joong-Seok Kim, Yeong-In Song, Christopher Yoon, Injin Park, Jeong-Wook Choi, Young-Bin Kim, Hee-Tae Lee, Kwang-Soo |
author_sort | Kim, Joong-Seok |
collection | PubMed |
description | 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)(2)D(3) exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) BsmI polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the BsmI polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p=0.069) and homozygote bb (84.7 vs. 72.7%; p=0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus. |
format | Text |
id | pubmed-2782210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27822102009-11-30 Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans Kim, Joong-Seok Kim, Yeong-In Song, Christopher Yoon, Injin Park, Jeong-Wook Choi, Young-Bin Kim, Hee-Tae Lee, Kwang-Soo J Korean Med Sci Original Article 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH)(2)D(3) exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) BsmI polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the BsmI polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p=0.069) and homozygote bb (84.7 vs. 72.7%; p=0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus. The Korean Academy of Medical Sciences 2005-06 2005-06-30 /pmc/articles/PMC2782210/ /pubmed/15953876 http://dx.doi.org/10.3346/jkms.2005.20.3.495 Text en Copyright © 2005 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Joong-Seok Kim, Yeong-In Song, Christopher Yoon, Injin Park, Jeong-Wook Choi, Young-Bin Kim, Hee-Tae Lee, Kwang-Soo Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title | Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title_full | Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title_fullStr | Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title_full_unstemmed | Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title_short | Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans |
title_sort | association of vitamin d receptor gene polymorphism and parkinson's disease in koreans |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782210/ https://www.ncbi.nlm.nih.gov/pubmed/15953876 http://dx.doi.org/10.3346/jkms.2005.20.3.495 |
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