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Mutations in mitochondrial DNA polymerase γ promote breast tumorigenesis

Decreased mitochondrial oxidative phosphorylation (OXPHOS) is one of the hallmarks of cancer. To date the identity of nuclear gene(s) responsible for decreased OXPHOS in tumors remains unknown. It is also unclear whether mutations in nuclear gene(s) responsible for decreased OXPHOS affect tumorigene...

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Detalles Bibliográficos
Autores principales:	Singh, Keshav K., Ayyasamy, Vanniarajan, Owens, Kjerstin M., Koul, Manika Sapru, Vujcic, Marija
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782392/ https://www.ncbi.nlm.nih.gov/pubmed/19629138 http://dx.doi.org/10.1038/jhg.2009.71

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