Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Accumulation of stochastic DNA damage throughout organisms’ lifespan is thought to contribute to aging. Conversely, aging appears phenotypically reproducible and regulated through genetic pathways such as the insulin-like growth factor-1 (IGF-1) and growth hormone (GH) receptors, which are central m...

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Detalles Bibliográficos
Autores principales: Garinis, George A., Uittenboogaard, Lieneke M., Stachelscheid, Heike, Fousteri, Maria, van Ijcken, Wilfred, Breit, Timo M., van Steeg, Harry, Mullenders, Leon H.F., van der Horst, Gijsbertus T.J., Brüning, Jens C., Niessen, Carien M., Hoeijmakers, Jan H.J., Schumacher, Björn
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782455/
https://www.ncbi.nlm.nih.gov/pubmed/19363488
http://dx.doi.org/10.1038/ncb1866

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