Cargando…
Gene therapy for red-green colour blindness in adult primates
Red-green colour blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing colour blindness using gene therapy was explored in experiments on adult monk...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782927/ https://www.ncbi.nlm.nih.gov/pubmed/19759534 http://dx.doi.org/10.1038/nature08401 |
_version_ | 1782174645792800768 |
---|---|
author | Mancuso, Katherine Hauswirth, William W. Li, Qiuhong Connor, Thomas B. Kuchenbecker, James A. Mauck, Matthew C. Neitz, Jay Neitz, Maureen |
author_facet | Mancuso, Katherine Hauswirth, William W. Li, Qiuhong Connor, Thomas B. Kuchenbecker, James A. Mauck, Matthew C. Neitz, Jay Neitz, Maureen |
author_sort | Mancuso, Katherine |
collection | PubMed |
description | Red-green colour blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing colour blindness using gene therapy was explored in experiments on adult monkeys that had been colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green colour-deficient primates was sufficient to produce trichromatic colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders. |
format | Text |
id | pubmed-2782927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-27829272010-04-08 Gene therapy for red-green colour blindness in adult primates Mancuso, Katherine Hauswirth, William W. Li, Qiuhong Connor, Thomas B. Kuchenbecker, James A. Mauck, Matthew C. Neitz, Jay Neitz, Maureen Nature Article Red-green colour blindness, which results from the absence of either the long- (L) or middle- (M) wavelength-sensitive visual photopigments, is the most common single locus genetic disorder. Here, the possibility of curing colour blindness using gene therapy was explored in experiments on adult monkeys that had been colour blind since birth. A third type of cone pigment was added to dichromatic retinas, providing the receptoral basis for trichromatic colour vision. This opened a new avenue to explore the requirements for establishing the neural circuits for a new dimension of colour sensation. Classic visual deprivation experiments1 have led to the expectation that neural connections established during development would not appropriately process an input that was not present from birth. Therefore, it was believed that treatment of congenital vision disorders would be ineffective unless administered to the very young. Here, however, addition of a third opsin in adult red-green colour-deficient primates was sufficient to produce trichromatic colour vision behaviour. Thus, trichromacy can arise from a single addition of a third cone class and it does not require an early developmental process. This provides a positive outlook for the potential of gene therapy to cure adult vision disorders. 2009-09-16 2009-10-08 /pmc/articles/PMC2782927/ /pubmed/19759534 http://dx.doi.org/10.1038/nature08401 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Mancuso, Katherine Hauswirth, William W. Li, Qiuhong Connor, Thomas B. Kuchenbecker, James A. Mauck, Matthew C. Neitz, Jay Neitz, Maureen Gene therapy for red-green colour blindness in adult primates |
title | Gene therapy for red-green colour blindness in adult primates |
title_full | Gene therapy for red-green colour blindness in adult primates |
title_fullStr | Gene therapy for red-green colour blindness in adult primates |
title_full_unstemmed | Gene therapy for red-green colour blindness in adult primates |
title_short | Gene therapy for red-green colour blindness in adult primates |
title_sort | gene therapy for red-green colour blindness in adult primates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782927/ https://www.ncbi.nlm.nih.gov/pubmed/19759534 http://dx.doi.org/10.1038/nature08401 |
work_keys_str_mv | AT mancusokatherine genetherapyforredgreencolourblindnessinadultprimates AT hauswirthwilliamw genetherapyforredgreencolourblindnessinadultprimates AT liqiuhong genetherapyforredgreencolourblindnessinadultprimates AT connorthomasb genetherapyforredgreencolourblindnessinadultprimates AT kuchenbeckerjamesa genetherapyforredgreencolourblindnessinadultprimates AT mauckmatthewc genetherapyforredgreencolourblindnessinadultprimates AT neitzjay genetherapyforredgreencolourblindnessinadultprimates AT neitzmaureen genetherapyforredgreencolourblindnessinadultprimates |