Cargando…

History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway

OBJECTIVE: To compare mortality rates for individuals with diabetes with and without a history of foot ulcer (HFU) and with that for the nondiabetic population. RESEARCH DESIGN AND METHODS: This population-based study included 155 diabetic individuals with an HFU, 1,339 diabetic individuals without...

Descripción completa

Detalles Bibliográficos
Autores principales: Iversen, Marjolein M., Tell, Grethe S., Riise, Trond, Hanestad, Berit R., Østbye, Truls, Graue, Marit, Midthjell, Kristian
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782976/
https://www.ncbi.nlm.nih.gov/pubmed/19729524
http://dx.doi.org/10.2337/dc09-0651
_version_ 1782174648644927488
author Iversen, Marjolein M.
Tell, Grethe S.
Riise, Trond
Hanestad, Berit R.
Østbye, Truls
Graue, Marit
Midthjell, Kristian
author_facet Iversen, Marjolein M.
Tell, Grethe S.
Riise, Trond
Hanestad, Berit R.
Østbye, Truls
Graue, Marit
Midthjell, Kristian
author_sort Iversen, Marjolein M.
collection PubMed
description OBJECTIVE: To compare mortality rates for individuals with diabetes with and without a history of foot ulcer (HFU) and with that for the nondiabetic population. RESEARCH DESIGN AND METHODS: This population-based study included 155 diabetic individuals with an HFU, 1,339 diabetic individuals without an HFU, and 63,632 nondiabetic individuals who were all followed for 10 years with mortality as the end point. RESULTS: During the follow-up period, a total of 49.0% of diabetic individuals with an HFU died, compared with 35.2% of diabetic individuals without an HFU and 10.5% of those without diabetes. In Cox regression analyses adjusted for age, sex, education, current smoking, and waist circumference, having an HFU was associated with more than a twofold (2.29 [95% CI 1.82–2.88]) hazard risk for mortality compared with that of the nondiabetic group. In corresponding analyses comparing diabetic individuals with and without an HFU, an HFU was associated with 47% increased mortality (1.47 [1.14–1.89]). Significant covariates were older age, male sex, and current smoking. After inclusion of A1C, insulin use, microalbuminuria, cardiovascular disease, and depression scores in the model, each was significantly related to life expectancy. CONCLUSIONS: AN HFU increased mortality risk among community-dwelling adults and elderly individuals with diabetes. The excess risk persisted after adjustment for comorbidity and depression scores, indicating that close clinical monitoring might be warranted among individuals with an HFU, who may be particularly vulnerable to adverse outcomes.
format Text
id pubmed-2782976
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-27829762010-12-01 History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway Iversen, Marjolein M. Tell, Grethe S. Riise, Trond Hanestad, Berit R. Østbye, Truls Graue, Marit Midthjell, Kristian Diabetes Care Original Research OBJECTIVE: To compare mortality rates for individuals with diabetes with and without a history of foot ulcer (HFU) and with that for the nondiabetic population. RESEARCH DESIGN AND METHODS: This population-based study included 155 diabetic individuals with an HFU, 1,339 diabetic individuals without an HFU, and 63,632 nondiabetic individuals who were all followed for 10 years with mortality as the end point. RESULTS: During the follow-up period, a total of 49.0% of diabetic individuals with an HFU died, compared with 35.2% of diabetic individuals without an HFU and 10.5% of those without diabetes. In Cox regression analyses adjusted for age, sex, education, current smoking, and waist circumference, having an HFU was associated with more than a twofold (2.29 [95% CI 1.82–2.88]) hazard risk for mortality compared with that of the nondiabetic group. In corresponding analyses comparing diabetic individuals with and without an HFU, an HFU was associated with 47% increased mortality (1.47 [1.14–1.89]). Significant covariates were older age, male sex, and current smoking. After inclusion of A1C, insulin use, microalbuminuria, cardiovascular disease, and depression scores in the model, each was significantly related to life expectancy. CONCLUSIONS: AN HFU increased mortality risk among community-dwelling adults and elderly individuals with diabetes. The excess risk persisted after adjustment for comorbidity and depression scores, indicating that close clinical monitoring might be warranted among individuals with an HFU, who may be particularly vulnerable to adverse outcomes. American Diabetes Association 2009-12 2009-09-03 /pmc/articles/PMC2782976/ /pubmed/19729524 http://dx.doi.org/10.2337/dc09-0651 Text en © 2009 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Iversen, Marjolein M.
Tell, Grethe S.
Riise, Trond
Hanestad, Berit R.
Østbye, Truls
Graue, Marit
Midthjell, Kristian
History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title_full History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title_fullStr History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title_full_unstemmed History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title_short History of Foot Ulcer Increases Mortality Among Individuals With Diabetes: Ten-year follow-up of the Nord-Trøndelag Health Study, Norway
title_sort history of foot ulcer increases mortality among individuals with diabetes: ten-year follow-up of the nord-trøndelag health study, norway
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782976/
https://www.ncbi.nlm.nih.gov/pubmed/19729524
http://dx.doi.org/10.2337/dc09-0651
work_keys_str_mv AT iversenmarjoleinm historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT tellgrethes historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT riisetrond historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT hanestadberitr historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT østbyetruls historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT grauemarit historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway
AT midthjellkristian historyoffootulcerincreasesmortalityamongindividualswithdiabetestenyearfollowupofthenordtrøndelaghealthstudynorway