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IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C

Genetic predisposition of nuclear factor-kappa B (NF-κB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case–control study to determine the associations of the polymorphisms within the promoter regions of N...

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Autores principales: He, Yongchao, Zhang, Hongwei, Yin, Jianhua, Xie, Jiaxin, Tan, Xiaojie, Liu, Shijian, Zhang, Qian, Li, Chengzhong, Zhao, Jun, Wang, Hongyang, Cao, Guangwen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783005/
https://www.ncbi.nlm.nih.gov/pubmed/19797428
http://dx.doi.org/10.1093/carcin/bgp226
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author He, Yongchao
Zhang, Hongwei
Yin, Jianhua
Xie, Jiaxin
Tan, Xiaojie
Liu, Shijian
Zhang, Qian
Li, Chengzhong
Zhao, Jun
Wang, Hongyang
Cao, Guangwen
author_facet He, Yongchao
Zhang, Hongwei
Yin, Jianhua
Xie, Jiaxin
Tan, Xiaojie
Liu, Shijian
Zhang, Qian
Li, Chengzhong
Zhao, Jun
Wang, Hongyang
Cao, Guangwen
author_sort He, Yongchao
collection PubMed
description Genetic predisposition of nuclear factor-kappa B (NF-κB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case–control study to determine the associations of the polymorphisms within the promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IkappaBalpha with the development of HCC. A total of 404 healthy controls, 482 non-HCC subjects with HBV infection and 202 patients with HCC were included. NFKB1 −94ATTG2 allele and GG allele in the 3′-untranslated region of NFKBIA were more prevalent in HCC patients than in the healthy controls. NFKBIA −826CT and NFKBIA −881AG allelic carriages were more prevalent in HCC patients than in the non-HCC subjects with HBV infection. The estimated haplotype frequency of NFKBIA promoter −881G−826T−519C was significantly higher in the patients with HCC than in the HBV-infected subjects without HCC (odds ratio = 3.142, P = 0.002). As compared with the HBV-infected subjects without HCC, NFKBIA −826 T and NFKBIA −881AG allelic carriages were only associated with HCC risk in the subjects with HBV genotype C. The association of NFKBIA −881AG allelic carriage with HCC risk was not affected by liver cirrhosis (LC) status, alanine aminotransferase level and hepatitis B e antigen status. By multivariate regression analysis, NFKB1 −94ATTG2, NFKBIA −826T, NFKBIA −881AG and HBV genotype C were independently associated with an increased risk of HCC. In conclusion, NFKB1 −94ATTG2 allele and haplotype −881G−826T−519C in NFKBIA promoter were associated with hepatocarcinogenesis. NFKBIA −826T and −881AG were associated with the risk of HCC in the subjects infected with HBV genotype C.
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spelling pubmed-27830052009-11-27 IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C He, Yongchao Zhang, Hongwei Yin, Jianhua Xie, Jiaxin Tan, Xiaojie Liu, Shijian Zhang, Qian Li, Chengzhong Zhao, Jun Wang, Hongyang Cao, Guangwen Carcinogenesis Molecular Epidemiology Genetic predisposition of nuclear factor-kappa B (NF-κB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case–control study to determine the associations of the polymorphisms within the promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IkappaBalpha with the development of HCC. A total of 404 healthy controls, 482 non-HCC subjects with HBV infection and 202 patients with HCC were included. NFKB1 −94ATTG2 allele and GG allele in the 3′-untranslated region of NFKBIA were more prevalent in HCC patients than in the healthy controls. NFKBIA −826CT and NFKBIA −881AG allelic carriages were more prevalent in HCC patients than in the non-HCC subjects with HBV infection. The estimated haplotype frequency of NFKBIA promoter −881G−826T−519C was significantly higher in the patients with HCC than in the HBV-infected subjects without HCC (odds ratio = 3.142, P = 0.002). As compared with the HBV-infected subjects without HCC, NFKBIA −826 T and NFKBIA −881AG allelic carriages were only associated with HCC risk in the subjects with HBV genotype C. The association of NFKBIA −881AG allelic carriage with HCC risk was not affected by liver cirrhosis (LC) status, alanine aminotransferase level and hepatitis B e antigen status. By multivariate regression analysis, NFKB1 −94ATTG2, NFKBIA −826T, NFKBIA −881AG and HBV genotype C were independently associated with an increased risk of HCC. In conclusion, NFKB1 −94ATTG2 allele and haplotype −881G−826T−519C in NFKBIA promoter were associated with hepatocarcinogenesis. NFKBIA −826T and −881AG were associated with the risk of HCC in the subjects infected with HBV genotype C. Oxford University Press 2009-11 2009-10-01 /pmc/articles/PMC2783005/ /pubmed/19797428 http://dx.doi.org/10.1093/carcin/bgp226 Text en © The Author 2009. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Molecular Epidemiology
He, Yongchao
Zhang, Hongwei
Yin, Jianhua
Xie, Jiaxin
Tan, Xiaojie
Liu, Shijian
Zhang, Qian
Li, Chengzhong
Zhao, Jun
Wang, Hongyang
Cao, Guangwen
IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title_full IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title_fullStr IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title_full_unstemmed IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title_short IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
title_sort ikappabalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis b virus genotype c
topic Molecular Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783005/
https://www.ncbi.nlm.nih.gov/pubmed/19797428
http://dx.doi.org/10.1093/carcin/bgp226
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