Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports

INTRODUCTION: Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. CASE PRESENTATION: We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type...

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Detalles Bibliográficos
Autores principales: Gregoriou, Stamatis, Chiolou, Zoe, Stefanaki, Christina, Zakopoulou, Niki, Rigopoulos, Dimitrios, Kontochristopoulos, George
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783063/
https://www.ncbi.nlm.nih.gov/pubmed/19946540
http://dx.doi.org/10.1186/1752-1947-3-123
Descripción
Sumario:INTRODUCTION: Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. CASE PRESENTATION: We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type 1; both patients also exhibited an abnormal immunological profile. CONCLUSION: Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this disorder.

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