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Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports

INTRODUCTION: Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. CASE PRESENTATION: We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type...

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Autores principales: Gregoriou, Stamatis, Chiolou, Zoe, Stefanaki, Christina, Zakopoulou, Niki, Rigopoulos, Dimitrios, Kontochristopoulos, George
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783063/
https://www.ncbi.nlm.nih.gov/pubmed/19946540
http://dx.doi.org/10.1186/1752-1947-3-123
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author Gregoriou, Stamatis
Chiolou, Zoe
Stefanaki, Christina
Zakopoulou, Niki
Rigopoulos, Dimitrios
Kontochristopoulos, George
author_facet Gregoriou, Stamatis
Chiolou, Zoe
Stefanaki, Christina
Zakopoulou, Niki
Rigopoulos, Dimitrios
Kontochristopoulos, George
author_sort Gregoriou, Stamatis
collection PubMed
description INTRODUCTION: Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. CASE PRESENTATION: We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type 1; both patients also exhibited an abnormal immunological profile. CONCLUSION: Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this disorder.
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spelling pubmed-27830632009-11-26 Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports Gregoriou, Stamatis Chiolou, Zoe Stefanaki, Christina Zakopoulou, Niki Rigopoulos, Dimitrios Kontochristopoulos, George J Med Case Reports Case report INTRODUCTION: Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. CASE PRESENTATION: We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type 1; both patients also exhibited an abnormal immunological profile. CONCLUSION: Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this disorder. BioMed Central 2009-11-13 /pmc/articles/PMC2783063/ /pubmed/19946540 http://dx.doi.org/10.1186/1752-1947-3-123 Text en Copyright ©2009 Gregoriou et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case report
Gregoriou, Stamatis
Chiolou, Zoe
Stefanaki, Christina
Zakopoulou, Niki
Rigopoulos, Dimitrios
Kontochristopoulos, George
Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title_full Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title_fullStr Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title_full_unstemmed Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title_short Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
title_sort pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783063/
https://www.ncbi.nlm.nih.gov/pubmed/19946540
http://dx.doi.org/10.1186/1752-1947-3-123
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