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Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report
INTRODUCTION: Paraneoplastic necrotizing myopathy is a rare disorder, described as a proximal, symmetrical, and rapidly progressing myopathy that is manifested as a paraneoplastic syndrome. Diagnosis is established via histological examination of the muscle biopsy. CASE PRESENTATION: We present the...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783095/ https://www.ncbi.nlm.nih.gov/pubmed/19946512 http://dx.doi.org/10.1186/1752-1947-3-95 |
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author | Silvestre, Joana Santos, Luis Batalha, Vitor del Rio, Ana Lima, Carlos Carvalho, Antonio Martins, Ana Miranda, Helena Cabral, Fatima Felix, Adelia Aleixo, Ana |
author_facet | Silvestre, Joana Santos, Luis Batalha, Vitor del Rio, Ana Lima, Carlos Carvalho, Antonio Martins, Ana Miranda, Helena Cabral, Fatima Felix, Adelia Aleixo, Ana |
author_sort | Silvestre, Joana |
collection | PubMed |
description | INTRODUCTION: Paraneoplastic necrotizing myopathy is a rare disorder, described as a proximal, symmetrical, and rapidly progressing myopathy that is manifested as a paraneoplastic syndrome. Diagnosis is established via histological examination of the muscle biopsy. CASE PRESENTATION: We present the case of a 53-year-old woman, born in Guinea-Bissau, with a history of locally advanced breast cancer, diagnosed ten months previously. The patient had experienced a progressively proximal muscle weakness of the lower extremities, which led to a total inability to walk. Upon neurological examination, the patient showed muscle weakness and atrophy in both proximal lower extremities without myalgia. Muscle strength was graded according to the Medical Research Council Scale as 2 out of 5 in the bilateral iliopsoas muscle, and 4 out of 5 in the bilateral quadriceps femoris. The deep-tendon reflexes were hypoactive. The laboratory examination showed increased values of serum creatinine kinase and myoglobin. An electromyogram showed an incomplete interference pattern during voluntary contraction in the iliopsoas and quadriceps femoris. The motor nerve conduction was 44.1 m/s and 44.3 m/s in the right and left tibial nerves, respectively, and 46.5 m/s and 46.1 m/s in the right and left peroneal nerves, respectively. The sensory motor nerve conductions and the compound motor action potential amplitudes were normal. These findings, despite not being specific, suggested a myopathy. Consequently, a muscle biopsy was performed. A biopsy specimen showed myopathic changes that were characteristic of a necrotizing myopathy. CONCLUSION: Treatment for this syndrome consists of controlling the tumor, and providing corticoid therapy. This led to the partial remission of the neurological manifestations. |
format | Text |
id | pubmed-2783095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27830952009-11-26 Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report Silvestre, Joana Santos, Luis Batalha, Vitor del Rio, Ana Lima, Carlos Carvalho, Antonio Martins, Ana Miranda, Helena Cabral, Fatima Felix, Adelia Aleixo, Ana J Med Case Reports Case report INTRODUCTION: Paraneoplastic necrotizing myopathy is a rare disorder, described as a proximal, symmetrical, and rapidly progressing myopathy that is manifested as a paraneoplastic syndrome. Diagnosis is established via histological examination of the muscle biopsy. CASE PRESENTATION: We present the case of a 53-year-old woman, born in Guinea-Bissau, with a history of locally advanced breast cancer, diagnosed ten months previously. The patient had experienced a progressively proximal muscle weakness of the lower extremities, which led to a total inability to walk. Upon neurological examination, the patient showed muscle weakness and atrophy in both proximal lower extremities without myalgia. Muscle strength was graded according to the Medical Research Council Scale as 2 out of 5 in the bilateral iliopsoas muscle, and 4 out of 5 in the bilateral quadriceps femoris. The deep-tendon reflexes were hypoactive. The laboratory examination showed increased values of serum creatinine kinase and myoglobin. An electromyogram showed an incomplete interference pattern during voluntary contraction in the iliopsoas and quadriceps femoris. The motor nerve conduction was 44.1 m/s and 44.3 m/s in the right and left tibial nerves, respectively, and 46.5 m/s and 46.1 m/s in the right and left peroneal nerves, respectively. The sensory motor nerve conductions and the compound motor action potential amplitudes were normal. These findings, despite not being specific, suggested a myopathy. Consequently, a muscle biopsy was performed. A biopsy specimen showed myopathic changes that were characteristic of a necrotizing myopathy. CONCLUSION: Treatment for this syndrome consists of controlling the tumor, and providing corticoid therapy. This led to the partial remission of the neurological manifestations. BioMed Central 2009-11-02 /pmc/articles/PMC2783095/ /pubmed/19946512 http://dx.doi.org/10.1186/1752-1947-3-95 Text en Copyright ©2009 Silvestre et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case report Silvestre, Joana Santos, Luis Batalha, Vitor del Rio, Ana Lima, Carlos Carvalho, Antonio Martins, Ana Miranda, Helena Cabral, Fatima Felix, Adelia Aleixo, Ana Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title | Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title_full | Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title_fullStr | Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title_full_unstemmed | Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title_short | Paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
title_sort | paraneoplastic necrotizing myopathy in a woman with breast cancer: a case report |
topic | Case report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783095/ https://www.ncbi.nlm.nih.gov/pubmed/19946512 http://dx.doi.org/10.1186/1752-1947-3-95 |
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