Transitions in infant learning are modulated by dopamine within the amygdala

Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function...

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Detalles Bibliográficos
Autores principales: Barr, Gordon A., Moriceau, Stephanie, Shionoya, Kiseko, Muzny, Kyle, Gao, Puhong, Wang, Shaoning, Sullivan, Regina M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783302/
https://www.ncbi.nlm.nih.gov/pubmed/19783994
http://dx.doi.org/10.1038/nn.2403
Descripción
Sumario:Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone–injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions; dopamine antagonism reinstated preference learning.

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