Transitions in infant learning are modulated by dopamine within the amygdala

Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function...

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Autores principales: Barr, Gordon A., Moriceau, Stephanie, Shionoya, Kiseko, Muzny, Kyle, Gao, Puhong, Wang, Shaoning, Sullivan, Regina M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783302/
https://www.ncbi.nlm.nih.gov/pubmed/19783994
http://dx.doi.org/10.1038/nn.2403
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author Barr, Gordon A.
Moriceau, Stephanie
Shionoya, Kiseko
Muzny, Kyle
Gao, Puhong
Wang, Shaoning
Sullivan, Regina M.
author_facet Barr, Gordon A.
Moriceau, Stephanie
Shionoya, Kiseko
Muzny, Kyle
Gao, Puhong
Wang, Shaoning
Sullivan, Regina M.
author_sort Barr, Gordon A.
collection PubMed
description Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone–injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions; dopamine antagonism reinstated preference learning.
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spelling pubmed-27833022010-05-01 Transitions in infant learning are modulated by dopamine within the amygdala Barr, Gordon A. Moriceau, Stephanie Shionoya, Kiseko Muzny, Kyle Gao, Puhong Wang, Shaoning Sullivan, Regina M. Nat Neurosci Article Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone–injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions; dopamine antagonism reinstated preference learning. 2009-09-27 2009-11 /pmc/articles/PMC2783302/ /pubmed/19783994 http://dx.doi.org/10.1038/nn.2403 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Barr, Gordon A.
Moriceau, Stephanie
Shionoya, Kiseko
Muzny, Kyle
Gao, Puhong
Wang, Shaoning
Sullivan, Regina M.
Transitions in infant learning are modulated by dopamine within the amygdala
title Transitions in infant learning are modulated by dopamine within the amygdala
title_full Transitions in infant learning are modulated by dopamine within the amygdala
title_fullStr Transitions in infant learning are modulated by dopamine within the amygdala
title_full_unstemmed Transitions in infant learning are modulated by dopamine within the amygdala
title_short Transitions in infant learning are modulated by dopamine within the amygdala
title_sort transitions in infant learning are modulated by dopamine within the amygdala
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783302/
https://www.ncbi.nlm.nih.gov/pubmed/19783994
http://dx.doi.org/10.1038/nn.2403
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