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Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes
All coronaviruses (CoVs), including the causative agent of severe acute respiratory syndrome (SARS), encode a nucleocapsid (N) protein that harbors two independent RNA binding domains of known structure, but poorly characterized RNA binding properties. We show here that the N-terminal domain (NTD) o...
Autores principales: | Grossoehme, Nicholas E., Li, Lichun, Keane, Sarah C., Liu, Pinghua, Dann, Charles E., Leibowitz, Julian L., Giedroc, David P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783395/ https://www.ncbi.nlm.nih.gov/pubmed/19782089 http://dx.doi.org/10.1016/j.jmb.2009.09.040 |
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