Knockout of Ku86 accelerates cellular senescence induced by high NaCl

NaCl induces DNA breaks, thus leading to cellular senescence. Here we showed that Ku86 deficiency accelerated the high NaCl-induced cellular senescence. We find that 1) high NaCl induces rapid cellular senescence in Ku86 deficient (xrs5) cells, 2) Ku86 deficiency shortens lifespan of C. elegans in h...

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Detalles Bibliográficos
Autores principales: Dmitrieva, Natalia I., Chen, Hua Tang, Nussenzweig, André, Burg, Maurice B.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783634/
https://www.ncbi.nlm.nih.gov/pubmed/19946467

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