Cargando…

Herpes Virus Amplicon Vectors

Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and...

Descripción completa

Detalles Bibliográficos
Autores principales: de Silva, Suresh, Bowers, William J.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783652/
https://www.ncbi.nlm.nih.gov/pubmed/19956558
http://dx.doi.org/10.3390/v1030594
_version_ 1782174698299195392
author de Silva, Suresh
Bowers, William J.
author_facet de Silva, Suresh
Bowers, William J.
author_sort de Silva, Suresh
collection PubMed
description Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
format Text
id pubmed-2783652
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-27836522009-12-01 Herpes Virus Amplicon Vectors de Silva, Suresh Bowers, William J. Viruses Review Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing. Molecular Diversity Preservation International (MDPI) 2009-10-29 /pmc/articles/PMC2783652/ /pubmed/19956558 http://dx.doi.org/10.3390/v1030594 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
de Silva, Suresh
Bowers, William J.
Herpes Virus Amplicon Vectors
title Herpes Virus Amplicon Vectors
title_full Herpes Virus Amplicon Vectors
title_fullStr Herpes Virus Amplicon Vectors
title_full_unstemmed Herpes Virus Amplicon Vectors
title_short Herpes Virus Amplicon Vectors
title_sort herpes virus amplicon vectors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783652/
https://www.ncbi.nlm.nih.gov/pubmed/19956558
http://dx.doi.org/10.3390/v1030594
work_keys_str_mv AT desilvasuresh herpesvirusampliconvectors
AT bowerswilliamj herpesvirusampliconvectors