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Herpes Virus Amplicon Vectors
Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783652/ https://www.ncbi.nlm.nih.gov/pubmed/19956558 http://dx.doi.org/10.3390/v1030594 |
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author | de Silva, Suresh Bowers, William J. |
author_facet | de Silva, Suresh Bowers, William J. |
author_sort | de Silva, Suresh |
collection | PubMed |
description | Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing. |
format | Text |
id | pubmed-2783652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-27836522009-12-01 Herpes Virus Amplicon Vectors de Silva, Suresh Bowers, William J. Viruses Review Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing. Molecular Diversity Preservation International (MDPI) 2009-10-29 /pmc/articles/PMC2783652/ /pubmed/19956558 http://dx.doi.org/10.3390/v1030594 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review de Silva, Suresh Bowers, William J. Herpes Virus Amplicon Vectors |
title | Herpes Virus Amplicon Vectors |
title_full | Herpes Virus Amplicon Vectors |
title_fullStr | Herpes Virus Amplicon Vectors |
title_full_unstemmed | Herpes Virus Amplicon Vectors |
title_short | Herpes Virus Amplicon Vectors |
title_sort | herpes virus amplicon vectors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783652/ https://www.ncbi.nlm.nih.gov/pubmed/19956558 http://dx.doi.org/10.3390/v1030594 |
work_keys_str_mv | AT desilvasuresh herpesvirusampliconvectors AT bowerswilliamj herpesvirusampliconvectors |