SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas

Lineage survival oncogenes are activated by somatic DNA alterations in cancers arising from the cell lineages in which these genes play a role in normal development.1,2 Here we show that a peak of genomic amplification on chromosome 3q26.33, found in squamous cell carcinomas (SCCs) of the lung and e...

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Detalles Bibliográficos
Autores principales: Bass, Adam J., Watanabe, Hideo, Mermel, Craig H., Yu, Soyoung, Perner, Sven, Verhaak, Roel G., Kim, So Young, Wardwell, Leslie, Tamayo, Pablo, Gat-Viks, Irit, Ramos, Alex H., Woo, Michele S., Weir, Barbara A., Getz, Gad, Beroukhim, Rameen, O’Kelly, Michael, Dutt, Amit, Rozenblatt-Rosen, Orit, Dziunycz, Piotr, Komisarof, Justin, Chirieac, Lucian R., LaFargue, Christopher J., Scheble, Veit, Wilbertz, Theresia, Ma, Changqing, Rao, Shilpa, Nakagawa, Hiroshi, Stairs, Douglas B., Lin, Lin, Giordano, Thomas J., Wagner, Patrick, Minna, John D., Gazdar, Adi F., Zhu, Chang Qi, Brose, Marcia S., Cecconello, Ivan, Ribeiro, Ulysses, Marie, Suely K., Dahl, Olav, Shivdasani, Ramesh A., Tsao, Ming-Sound, Rubin, Mark A., Wong, Kwok K., Regev, Aviv, Hahn, William C., Beer, David G., Rustgi, Anil K., Meyerson, Matthew
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783775/
https://www.ncbi.nlm.nih.gov/pubmed/19801978
http://dx.doi.org/10.1038/ng.465

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