Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin

A library of 5″-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities we...

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Autores principales: Zhang, Jianjun, Keller, Katherine, Takemoto, Jon Y., Bensaci, Mekki, Litke, Anthony, Czyryca, Przemyslaw Greg, Chang, Cheng-Wei Tom
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783947/
https://www.ncbi.nlm.nih.gov/pubmed/19629142
http://dx.doi.org/10.1038/ja.2009.66
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author Zhang, Jianjun
Keller, Katherine
Takemoto, Jon Y.
Bensaci, Mekki
Litke, Anthony
Czyryca, Przemyslaw Greg
Chang, Cheng-Wei Tom
author_facet Zhang, Jianjun
Keller, Katherine
Takemoto, Jon Y.
Bensaci, Mekki
Litke, Anthony
Czyryca, Przemyslaw Greg
Chang, Cheng-Wei Tom
author_sort Zhang, Jianjun
collection PubMed
description A library of 5″-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed which may lead to the development of novel therapeutic practices in the battle against infectious bacteria.
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spelling pubmed-27839472010-04-01 Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin Zhang, Jianjun Keller, Katherine Takemoto, Jon Y. Bensaci, Mekki Litke, Anthony Czyryca, Przemyslaw Greg Chang, Cheng-Wei Tom J Antibiot (Tokyo) Article A library of 5″-modified neomycin derivatives were synthesized for an antibacterial structure-activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Antibacterial activities were measured when combined with other clinically used antibiotics. Significant synergistic activities were observed which may lead to the development of novel therapeutic practices in the battle against infectious bacteria. 2009-07-24 2009-10 /pmc/articles/PMC2783947/ /pubmed/19629142 http://dx.doi.org/10.1038/ja.2009.66 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhang, Jianjun
Keller, Katherine
Takemoto, Jon Y.
Bensaci, Mekki
Litke, Anthony
Czyryca, Przemyslaw Greg
Chang, Cheng-Wei Tom
Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title_full Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title_fullStr Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title_full_unstemmed Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title_short Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
title_sort synthesis and combinational antibacterial study of 5″-modified neomycin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783947/
https://www.ncbi.nlm.nih.gov/pubmed/19629142
http://dx.doi.org/10.1038/ja.2009.66
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AT litkeanthony synthesisandcombinationalantibacterialstudyof5modifiedneomycin
AT czyrycaprzemyslawgreg synthesisandcombinationalantibacterialstudyof5modifiedneomycin
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