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Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients

Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is used to prevent graft rejection in renal transplant recipients. MPA is glucuronidated to the metabolite MPAG, which exhibits enterohepatic recirculation (EHC). MPA binds for 97% and MPAG binds for 82% to plasma proteins....

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Detalles Bibliográficos
Autores principales:	de Winter, Brenda C. M., van Gelder, Teun, Sombogaard, Ferdi, Shaw, Leslie M., van Hest, Reinier M., Mathot, Ron A. A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784070/ https://www.ncbi.nlm.nih.gov/pubmed/19904584 http://dx.doi.org/10.1007/s10928-009-9136-6

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