Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment

How naïve CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is poorly understood. Here we show that the basic helix-loop-helix transcription factor Dec2 is selectively expressed in T(H)2 cells. CD4(+) T cells from Dec2-deficient mice exhibits defective T(H)2 differentiation in vitro and i...

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Detalles Bibliográficos
Autores principales: Yang, Xuexian O., Angkasekwinai, Pornpimon, Zhu, Jinfang, Peng, Juan, Liu, Zhiduo, Nurieva, Roza, Liu, Xikui, Chung, Yeonseok, Chang, Seon Hee, Sun, Bing, Dong, Chen
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784129/
https://www.ncbi.nlm.nih.gov/pubmed/19881507
http://dx.doi.org/10.1038/ni.1821

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