Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

In eukaryotes, sphingolipids (SLs) are important membrane components and powerful signaling molecules. In Leishmania, the major group of SLs is inositol phosphorylceramide (IPC), which is common in yeast and Trypanosomatids but absent in mammals. In contrast, sphingomyelin is not synthesized by Leis...

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Detalles Bibliográficos
Autores principales: Zhang, Ou, Wilson, Mattie C., Xu, Wei, Hsu, Fong-Fu, Turk, John, Kuhlmann, F. Matthew, Wang, Yingwei, Soong, Lynn, Key, Phillip, Beverley, Stephen M., Zhang, Kai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784226/
https://www.ncbi.nlm.nih.gov/pubmed/20011126
http://dx.doi.org/10.1371/journal.ppat.1000692

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