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Insights into gliomagenesis: systems biology unravels key pathways

Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterati...

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Detalles Bibliográficos
Autores principales: de Souza, Sandro J, Stransky, Beatriz, Camargo, Anamaria A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784304/
https://www.ncbi.nlm.nih.gov/pubmed/19863775
http://dx.doi.org/10.1186/gm101
Descripción
Sumario:Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterations that drive the genesis of a tumor. Recently, a systems biology approach has been used to characterize such alterations and find associations between them and the process of gliomagenesis. Here, we discuss some implications of this strategy for the development of new therapeutic and diagnostic protocols for cancer.