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Insights into gliomagenesis: systems biology unravels key pathways

Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterati...

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Detalles Bibliográficos
Autores principales: de Souza, Sandro J, Stransky, Beatriz, Camargo, Anamaria A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784304/
https://www.ncbi.nlm.nih.gov/pubmed/19863775
http://dx.doi.org/10.1186/gm101
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author de Souza, Sandro J
Stransky, Beatriz
Camargo, Anamaria A
author_facet de Souza, Sandro J
Stransky, Beatriz
Camargo, Anamaria A
author_sort de Souza, Sandro J
collection PubMed
description Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterations that drive the genesis of a tumor. Recently, a systems biology approach has been used to characterize such alterations and find associations between them and the process of gliomagenesis. Here, we discuss some implications of this strategy for the development of new therapeutic and diagnostic protocols for cancer.
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spelling pubmed-27843042010-10-27 Insights into gliomagenesis: systems biology unravels key pathways de Souza, Sandro J Stransky, Beatriz Camargo, Anamaria A Genome Med Minireview Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterations that drive the genesis of a tumor. Recently, a systems biology approach has been used to characterize such alterations and find associations between them and the process of gliomagenesis. Here, we discuss some implications of this strategy for the development of new therapeutic and diagnostic protocols for cancer. BioMed Central 2009-10-27 /pmc/articles/PMC2784304/ /pubmed/19863775 http://dx.doi.org/10.1186/gm101 Text en Copyright ©2009 BioMed Central Ltd
spellingShingle Minireview
de Souza, Sandro J
Stransky, Beatriz
Camargo, Anamaria A
Insights into gliomagenesis: systems biology unravels key pathways
title Insights into gliomagenesis: systems biology unravels key pathways
title_full Insights into gliomagenesis: systems biology unravels key pathways
title_fullStr Insights into gliomagenesis: systems biology unravels key pathways
title_full_unstemmed Insights into gliomagenesis: systems biology unravels key pathways
title_short Insights into gliomagenesis: systems biology unravels key pathways
title_sort insights into gliomagenesis: systems biology unravels key pathways
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784304/
https://www.ncbi.nlm.nih.gov/pubmed/19863775
http://dx.doi.org/10.1186/gm101
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