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Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we used ChIP-chip and gene expression profiling to define the relationship between the epigenetic landscape, sites of HIF-1 b...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784328/ https://www.ncbi.nlm.nih.gov/pubmed/19828020 http://dx.doi.org/10.1186/gb-2009-10-10-r113 |