VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

INTRODUCTION: Prevention of lymphocyte apoptosis by caspase inhibition has been proposed as a novel treatment approach in sepsis. However, it has not been clearly demonstrated that caspase inhibitors improve survival in sepsis models when dosed post-insult. Also, there are concerns that caspase inhi...

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Detalles Bibliográficos
Autores principales: Weber, Peter, Wang, Ping, Maddens, Stephane, Wang, Paul SH, Wu, Rongqian, Miksa, Michael, Dong, Weifeng, Mortimore, Michael, Golec, Julian MC, Charlton, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784364/
https://www.ncbi.nlm.nih.gov/pubmed/19740426
http://dx.doi.org/10.1186/cc8041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784364/
https://www.ncbi.nlm.nih.gov/pubmed/19740426
http://dx.doi.org/10.1186/cc8041

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