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Migraine pathogenesis and state of pharmacological treatment options
Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presenta...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784479/ https://www.ncbi.nlm.nih.gov/pubmed/19917094 http://dx.doi.org/10.1186/1741-7015-7-71 |
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author | Sprenger, Till Goadsby, Peter J |
author_facet | Sprenger, Till Goadsby, Peter J |
author_sort | Sprenger, Till |
collection | PubMed |
description | Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presentation. This review discusses the current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. Acute and preventive migraine treatment approaches are briefly covered with a focus on shortcomings of the currently available treatment options. A number of different receptors, such as calcitonin gene-related peptide (CGRP), TRPV1 and glutamate receptors, are currently being targeted by potential novel migraine therapeutics. The prospects of this research are exciting and are likely to improve patient care. |
format | Text |
id | pubmed-2784479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27844792009-11-27 Migraine pathogenesis and state of pharmacological treatment options Sprenger, Till Goadsby, Peter J BMC Med Minireview Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presentation. This review discusses the current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. Acute and preventive migraine treatment approaches are briefly covered with a focus on shortcomings of the currently available treatment options. A number of different receptors, such as calcitonin gene-related peptide (CGRP), TRPV1 and glutamate receptors, are currently being targeted by potential novel migraine therapeutics. The prospects of this research are exciting and are likely to improve patient care. BioMed Central 2009-11-16 /pmc/articles/PMC2784479/ /pubmed/19917094 http://dx.doi.org/10.1186/1741-7015-7-71 Text en Copyright ©2009 Sprenger and Goadsby; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireview Sprenger, Till Goadsby, Peter J Migraine pathogenesis and state of pharmacological treatment options |
title | Migraine pathogenesis and state of pharmacological treatment options |
title_full | Migraine pathogenesis and state of pharmacological treatment options |
title_fullStr | Migraine pathogenesis and state of pharmacological treatment options |
title_full_unstemmed | Migraine pathogenesis and state of pharmacological treatment options |
title_short | Migraine pathogenesis and state of pharmacological treatment options |
title_sort | migraine pathogenesis and state of pharmacological treatment options |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784479/ https://www.ncbi.nlm.nih.gov/pubmed/19917094 http://dx.doi.org/10.1186/1741-7015-7-71 |
work_keys_str_mv | AT sprengertill migrainepathogenesisandstateofpharmacologicaltreatmentoptions AT goadsbypeterj migrainepathogenesisandstateofpharmacologicaltreatmentoptions |