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The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

BACKGROUND: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association...

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Autores principales: Castillejo, Adela, Mata-Balaguer, Trinidad, Guarinos, Carla, Castillejo, María-Isabel, Martínez-Cantó, Ana, Barberá, Víctor-Manuel, Montenegro, Paola, Ochoa, Enrique, Lázaro, Rafael, Guillén-Ponce, Carmen, Carrato, Alfredo, Soto, José-Luís
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784798/
https://www.ncbi.nlm.nih.gov/pubmed/19930569
http://dx.doi.org/10.1186/1471-2407-9-406
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author Castillejo, Adela
Mata-Balaguer, Trinidad
Guarinos, Carla
Castillejo, María-Isabel
Martínez-Cantó, Ana
Barberá, Víctor-Manuel
Montenegro, Paola
Ochoa, Enrique
Lázaro, Rafael
Guillén-Ponce, Carmen
Carrato, Alfredo
Soto, José-Luís
author_facet Castillejo, Adela
Mata-Balaguer, Trinidad
Guarinos, Carla
Castillejo, María-Isabel
Martínez-Cantó, Ana
Barberá, Víctor-Manuel
Montenegro, Paola
Ochoa, Enrique
Lázaro, Rafael
Guillén-Ponce, Carmen
Carrato, Alfredo
Soto, José-Luís
author_sort Castillejo, Adela
collection PubMed
description BACKGROUND: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. METHODS: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. RESULTS: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. CONCLUSION: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.
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spelling pubmed-27847982009-11-28 The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study Castillejo, Adela Mata-Balaguer, Trinidad Guarinos, Carla Castillejo, María-Isabel Martínez-Cantó, Ana Barberá, Víctor-Manuel Montenegro, Paola Ochoa, Enrique Lázaro, Rafael Guillén-Ponce, Carmen Carrato, Alfredo Soto, José-Luís BMC Cancer Research Article BACKGROUND: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. METHODS: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. RESULTS: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. CONCLUSION: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population. BioMed Central 2009-11-20 /pmc/articles/PMC2784798/ /pubmed/19930569 http://dx.doi.org/10.1186/1471-2407-9-406 Text en Copyright ©2009 Castillejo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Castillejo, Adela
Mata-Balaguer, Trinidad
Guarinos, Carla
Castillejo, María-Isabel
Martínez-Cantó, Ana
Barberá, Víctor-Manuel
Montenegro, Paola
Ochoa, Enrique
Lázaro, Rafael
Guillén-Ponce, Carmen
Carrato, Alfredo
Soto, José-Luís
The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title_full The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title_fullStr The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title_full_unstemmed The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title_short The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study
title_sort int7g24a variant of transforming growth factor-beta receptor type i is a risk factor for colorectal cancer in the male spanish population: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784798/
https://www.ncbi.nlm.nih.gov/pubmed/19930569
http://dx.doi.org/10.1186/1471-2407-9-406
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