HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()

Tuberculosis (TB) patients with strains common to other recent cases (‘clustering’) suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the pr...

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Autores principales: Houben, Rein M.G.J., Crampin, Amelia C., Mallard, Kim, Mwaungulu, J. Nimrod, Yates, Malcolm D., Mwaungulu, Frank D., Ngwira, Bagrey M.M., French, Neil, Fine, Paul E.M., Glynn, Judith R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Society Meeting Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784949/
https://www.ncbi.nlm.nih.gov/pubmed/19362727
http://dx.doi.org/10.1016/j.trstmh.2009.03.013
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author Houben, Rein M.G.J.
Crampin, Amelia C.
Mallard, Kim
Mwaungulu, J. Nimrod
Yates, Malcolm D.
Mwaungulu, Frank D.
Ngwira, Bagrey M.M.
French, Neil
Fine, Paul E.M.
Glynn, Judith R.
author_facet Houben, Rein M.G.J.
Crampin, Amelia C.
Mallard, Kim
Mwaungulu, J. Nimrod
Yates, Malcolm D.
Mwaungulu, Frank D.
Ngwira, Bagrey M.M.
French, Neil
Fine, Paul E.M.
Glynn, Judith R.
author_sort Houben, Rein M.G.J.
collection PubMed
description Tuberculosis (TB) patients with strains common to other recent cases (‘clustering’) suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the proportion clustered. Sex-period-adjusted odds ratios for the association of HIV and clustering were 1.26 (95% CI 0.4–4.1) for ages 15–25 years, 1.40 (0.9–2.3) for 25–50 years and 10.44 (2.3–47.9) for >50 years and remained stable over two periods examined. These results suggest that HIV increases the proportion of TB due to recent transmission in the elderly.
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spelling pubmed-27849492009-12-10 HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi() Houben, Rein M.G.J. Crampin, Amelia C. Mallard, Kim Mwaungulu, J. Nimrod Yates, Malcolm D. Mwaungulu, Frank D. Ngwira, Bagrey M.M. French, Neil Fine, Paul E.M. Glynn, Judith R. Trans R Soc Trop Med Hyg Society Meeting Paper Tuberculosis (TB) patients with strains common to other recent cases (‘clustering’) suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the proportion clustered. Sex-period-adjusted odds ratios for the association of HIV and clustering were 1.26 (95% CI 0.4–4.1) for ages 15–25 years, 1.40 (0.9–2.3) for 25–50 years and 10.44 (2.3–47.9) for >50 years and remained stable over two periods examined. These results suggest that HIV increases the proportion of TB due to recent transmission in the elderly. Oxford University Press 2009-12 /pmc/articles/PMC2784949/ /pubmed/19362727 http://dx.doi.org/10.1016/j.trstmh.2009.03.013 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Society Meeting Paper
Houben, Rein M.G.J.
Crampin, Amelia C.
Mallard, Kim
Mwaungulu, J. Nimrod
Yates, Malcolm D.
Mwaungulu, Frank D.
Ngwira, Bagrey M.M.
French, Neil
Fine, Paul E.M.
Glynn, Judith R.
HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title_full HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title_fullStr HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title_full_unstemmed HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title_short HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi()
title_sort hiv and the risk of tuberculosis due to recent transmission over 12 years in karonga district, malawi()
topic Society Meeting Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784949/
https://www.ncbi.nlm.nih.gov/pubmed/19362727
http://dx.doi.org/10.1016/j.trstmh.2009.03.013
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