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Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome
BACKGROUND/AIMS: Serum levels of highly sensitive C-reactive protein (hsCRP), a vascular inflammatory marker, may predict the development of cardiovascular disease (CVD) and type 2 diabetes. Women with polycystic ovary syndrome (PCOS) are at greater risk for type 2 diabetes and CVD. The aim of this...
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Formato: | Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784979/ https://www.ncbi.nlm.nih.gov/pubmed/19949734 http://dx.doi.org/10.3904/kjim.2009.24.4.350 |
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author | Oh, Ji Young Lee, Ji-Ah Lee, Hyejin Oh, Jee-Young Sung, Yeon-Ah Chung, Hyewon |
author_facet | Oh, Ji Young Lee, Ji-Ah Lee, Hyejin Oh, Jee-Young Sung, Yeon-Ah Chung, Hyewon |
author_sort | Oh, Ji Young |
collection | PubMed |
description | BACKGROUND/AIMS: Serum levels of highly sensitive C-reactive protein (hsCRP), a vascular inflammatory marker, may predict the development of cardiovascular disease (CVD) and type 2 diabetes. Women with polycystic ovary syndrome (PCOS) are at greater risk for type 2 diabetes and CVD. The aim of this study was to compare hsCRP levels between normal weight women with PCOS and controls with a normal menstrual cycle and to determine the factors associated with serum hsCRP levels. METHODS: Thirty-nine lean PCOS patients and 24 healthy, regular cycling women were enrolled in this study. We performed anthropometric measurements, fat computed tomography (CT), and blood sampling to determine blood chemistry and levels of hsCRP, gonadotropins, testosterone, and sex-hormone binding globulin. We also conducted 75-g oral glucose-tolerance test and euglycemic hyperinsulinemic clamp to assess insulin sensitivity. RESULTS: Serum hsCRP concentrations were higher in women with PCOS than in women with regular mensturation. However, this difference was no longer significant after adjusting for body mass index (BMI). hsCRP levels were correlated with waist circumference (r=0.46, p<0.01), BMI (r=0.46, p<0.01), visceral fat area (r=0.45, p<0.01), and systolic (r=0.42, p<0.05) and diastolic blood pressure (r=0.39, p<0.05). hsCRP also tended to be negatively associated with insulin-mediated glucose uptake (IMGU) (r=-0.31, p=0.07). A multiple regression analysis revealed that BMI (β=0.29, p<0.05), systolic blood pressure (β=0.39, p<0.01), and IMGU (β=-0.31, p<0.05) predicted serum hsCRP levels in women with PCOS. CONCLUSIONS: PCOS by itself does not seem to be associated with increased hsCRP levels, whereas known CVD risk factors affect serum hsCRP levels in PCOS. |
format | Text |
id | pubmed-2784979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-27849792009-12-01 Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome Oh, Ji Young Lee, Ji-Ah Lee, Hyejin Oh, Jee-Young Sung, Yeon-Ah Chung, Hyewon Korean J Intern Med Original Article BACKGROUND/AIMS: Serum levels of highly sensitive C-reactive protein (hsCRP), a vascular inflammatory marker, may predict the development of cardiovascular disease (CVD) and type 2 diabetes. Women with polycystic ovary syndrome (PCOS) are at greater risk for type 2 diabetes and CVD. The aim of this study was to compare hsCRP levels between normal weight women with PCOS and controls with a normal menstrual cycle and to determine the factors associated with serum hsCRP levels. METHODS: Thirty-nine lean PCOS patients and 24 healthy, regular cycling women were enrolled in this study. We performed anthropometric measurements, fat computed tomography (CT), and blood sampling to determine blood chemistry and levels of hsCRP, gonadotropins, testosterone, and sex-hormone binding globulin. We also conducted 75-g oral glucose-tolerance test and euglycemic hyperinsulinemic clamp to assess insulin sensitivity. RESULTS: Serum hsCRP concentrations were higher in women with PCOS than in women with regular mensturation. However, this difference was no longer significant after adjusting for body mass index (BMI). hsCRP levels were correlated with waist circumference (r=0.46, p<0.01), BMI (r=0.46, p<0.01), visceral fat area (r=0.45, p<0.01), and systolic (r=0.42, p<0.05) and diastolic blood pressure (r=0.39, p<0.05). hsCRP also tended to be negatively associated with insulin-mediated glucose uptake (IMGU) (r=-0.31, p=0.07). A multiple regression analysis revealed that BMI (β=0.29, p<0.05), systolic blood pressure (β=0.39, p<0.01), and IMGU (β=-0.31, p<0.05) predicted serum hsCRP levels in women with PCOS. CONCLUSIONS: PCOS by itself does not seem to be associated with increased hsCRP levels, whereas known CVD risk factors affect serum hsCRP levels in PCOS. The Korean Association of Internal Medicine 2009-12 2009-11-27 /pmc/articles/PMC2784979/ /pubmed/19949734 http://dx.doi.org/10.3904/kjim.2009.24.4.350 Text en Copyright © 2009 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Oh, Ji Young Lee, Ji-Ah Lee, Hyejin Oh, Jee-Young Sung, Yeon-Ah Chung, Hyewon Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title | Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title_full | Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title_fullStr | Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title_full_unstemmed | Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title_short | Serum C-Reactive Protein Levels in Normal-Weight Polycystic Ovary Syndrome |
title_sort | serum c-reactive protein levels in normal-weight polycystic ovary syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784979/ https://www.ncbi.nlm.nih.gov/pubmed/19949734 http://dx.doi.org/10.3904/kjim.2009.24.4.350 |
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