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Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria
BACKGROUND/AIMS: No definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis. METHODS: We...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784980/ https://www.ncbi.nlm.nih.gov/pubmed/19949735 http://dx.doi.org/10.3904/kjim.2009.24.4.356 |
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author | Kim, Byung Soo Kim, Yong Kyun Shin, Young Shin Kim, Young Ok Song, Ho Cheol Kim, Yong Soo Choi, Euy Jin |
author_facet | Kim, Byung Soo Kim, Yong Kyun Shin, Young Shin Kim, Young Ok Song, Ho Cheol Kim, Yong Soo Choi, Euy Jin |
author_sort | Kim, Byung Soo |
collection | PubMed |
description | BACKGROUND/AIMS: No definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis. METHODS: We retrospectively evaluated 156 subjects with IMH who had a renal biopsy performed. Of the 156 subjects, 33.3% were diagnosed with IgA nephropathy, 23.7% with mesangial proliferative glomerulonephritis, 15.4% with glomerular minor lesion, and 12.8% with thin basement membrane nephropathy; 6.4% had normal biopsies. RESULTS: We followed up with 100 subjects for about 31 months. During this follow-up period, two subjects who had received a pathologic diagnosis of IgA nephropathy developed chronic kidney disease. During the course of the study, one of these subjects presented with proteinuria and hypertension and the other with proteinuria. The overall incidences of proteinuria and hypertension were 6% and 5% respectively. CONCLUSIONS: The prognosis for patients with IMH was relatively favorable, but patients developing proteinuria and/or hypertension require careful observation and management during the follow-up period. |
format | Text |
id | pubmed-2784980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-27849802009-12-01 Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria Kim, Byung Soo Kim, Yong Kyun Shin, Young Shin Kim, Young Ok Song, Ho Cheol Kim, Yong Soo Choi, Euy Jin Korean J Intern Med Original Article BACKGROUND/AIMS: No definite conclusions have been reached about the natural history of patients with isolated microscopic hematuria (IMH). In this study, we observed the natural history of patients with IMH and examined factors related to a pathologic diagnosis and subsequent prognosis. METHODS: We retrospectively evaluated 156 subjects with IMH who had a renal biopsy performed. Of the 156 subjects, 33.3% were diagnosed with IgA nephropathy, 23.7% with mesangial proliferative glomerulonephritis, 15.4% with glomerular minor lesion, and 12.8% with thin basement membrane nephropathy; 6.4% had normal biopsies. RESULTS: We followed up with 100 subjects for about 31 months. During this follow-up period, two subjects who had received a pathologic diagnosis of IgA nephropathy developed chronic kidney disease. During the course of the study, one of these subjects presented with proteinuria and hypertension and the other with proteinuria. The overall incidences of proteinuria and hypertension were 6% and 5% respectively. CONCLUSIONS: The prognosis for patients with IMH was relatively favorable, but patients developing proteinuria and/or hypertension require careful observation and management during the follow-up period. The Korean Association of Internal Medicine 2009-12 2009-11-27 /pmc/articles/PMC2784980/ /pubmed/19949735 http://dx.doi.org/10.3904/kjim.2009.24.4.356 Text en Copyright © 2009 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Byung Soo Kim, Yong Kyun Shin, Young Shin Kim, Young Ok Song, Ho Cheol Kim, Yong Soo Choi, Euy Jin Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title | Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title_full | Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title_fullStr | Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title_full_unstemmed | Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title_short | Natural History and Renal Pathology in Patients with Isolated Microscopic Hematuria |
title_sort | natural history and renal pathology in patients with isolated microscopic hematuria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784980/ https://www.ncbi.nlm.nih.gov/pubmed/19949735 http://dx.doi.org/10.3904/kjim.2009.24.4.356 |
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