Cargando…
Hydrophobic Core Mutations Associated with Cataract Development in Mice Destabilize Human γD-Crystallin
The human eye lens is composed of fiber cells packed with crystallins up to 450 mg/ml. Human γD-crystallin (HγD-Crys) is a monomeric, two-domain protein of the lens central nucleus. Both domains of this long lived protein have double Greek key β-sheet folds with well packed hydrophobic cores. Three...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785171/ https://www.ncbi.nlm.nih.gov/pubmed/19758984 http://dx.doi.org/10.1074/jbc.M109.031344 |