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Hydrophobic Core Mutations Associated with Cataract Development in Mice Destabilize Human γD-Crystallin

The human eye lens is composed of fiber cells packed with crystallins up to 450 mg/ml. Human γD-crystallin (HγD-Crys) is a monomeric, two-domain protein of the lens central nucleus. Both domains of this long lived protein have double Greek key β-sheet folds with well packed hydrophobic cores. Three...

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Detalles Bibliográficos
Autores principales:	Moreau, Kate L., King, Jonathan
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785171/ https://www.ncbi.nlm.nih.gov/pubmed/19758984 http://dx.doi.org/10.1074/jbc.M109.031344

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