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Structure-based Mechanism of ADP-ribosylation by Sirtuins

Sirtuins comprise a family of enzymes found in all organisms, where they play a role in diverse processes including transcriptional silencing, aging, regulation of transcription, and metabolism. The predominant reaction catalyzed by these enzymes is NAD(+)-dependent lysine deacetylation, although so...

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Detalles Bibliográficos
Autores principales:	Hawse, William F., Wolberger, Cynthia
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785207/ https://www.ncbi.nlm.nih.gov/pubmed/19801667 http://dx.doi.org/10.1074/jbc.M109.024521

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