Immunoglobulin D enhances immune surveillance by activating antimicrobial, pro-inflammatory and B cell-stimulating programs in basophils

Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells co-express with IgM through alternative RNA splicing. We found active T cell-dependent and T cell-independent IgM-to-IgD class switching in human upper respiratory mucosa B cells. This process required activation-induced cyt...

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Detalles Bibliográficos
Autores principales: Chen, Kang, Xu, Weifeng, Wilson, Melanie, He, Bing, Miller, Norman W., Bengten, Eva, Edholm, Eva-Stina, Santini, Paul A., Rath, Poonam, Chiu, April, Cattalini, Marco, Litzman, Jiri, Bussel, James, Huang, Bihui, Meini, Antonella, Riesbeck, Kristian, Cunningham-Rundles, Charlotte, Plebani, Alessandro, Cerutti, Andrea
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785232/
https://www.ncbi.nlm.nih.gov/pubmed/19561614
http://dx.doi.org/10.1038/ni.1748

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