Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1

BACKGROUND: Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved in the development and persistency of pain symptoms. We thus hypothesize that neuropathic pain may be attenuated by down-regulation of GCH1 expression...

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Detalles Bibliográficos
Autores principales: Kim, Sung Jin, Lee, Won Il, Lee, Yoon Sun, Kim, Dong Hou, Chang, Jin Woo, Kim, Seong Who, Lee, Heuiran
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785765/
https://www.ncbi.nlm.nih.gov/pubmed/19922668
http://dx.doi.org/10.1186/1744-8069-5-67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785765/
https://www.ncbi.nlm.nih.gov/pubmed/19922668
http://dx.doi.org/10.1186/1744-8069-5-67

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