Innate Immune and Chemically Triggered Oxidative Stress Modifies Translational Fidelity

Translational fidelity, essential for protein and cell function, requires accurate tRNA aminoacylation. Purified aminoacyl-tRNA synthetases exhibit a fidelity of 1 error per 10,000 to 100,000 couplings 1, 2. The accuracy of tRNA aminoacylation in vivo is uncertain, however, and might be considerably...

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Detalles Bibliográficos
Autores principales: Netzer, Nir, Goodenbour, Jeffrey M., David, Alexandre, Dittmar, Kimberly A., Jones, Richard B., Schneider, Jeffrey R., Boone, David, Eves, Eva M., Rosner, Marsha R., Gibbs, James S., Embry, Alan, Dolan, Brian, Das, Suman, Hickman, Heather, Berglund, Peter, Bennink, Jack R., Yewdell, Jonathan W., Pan, Tao
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785853/
https://www.ncbi.nlm.nih.gov/pubmed/19940929
http://dx.doi.org/10.1038/nature08576

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