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Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage

INTRODUCTION: Cardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in periphe...

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Autores principales: Heyer, Laurent, Mebazaa, Alexandre, Gayat, Etienne, Resche-Rigon, Matthieu, Rabuel, Christophe, Rezlan, Eva, Lukascewicz, Anne-Claire, Madadaki, Catharina, Pirracchio, Romain, Schurando, Patrick, Morel, Olivier, Fargeaudou, Yann, Payen, Didier
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786110/
https://www.ncbi.nlm.nih.gov/pubmed/19951392
http://dx.doi.org/10.1186/cc8006
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author Heyer, Laurent
Mebazaa, Alexandre
Gayat, Etienne
Resche-Rigon, Matthieu
Rabuel, Christophe
Rezlan, Eva
Lukascewicz, Anne-Claire
Madadaki, Catharina
Pirracchio, Romain
Schurando, Patrick
Morel, Olivier
Fargeaudou, Yann
Payen, Didier
author_facet Heyer, Laurent
Mebazaa, Alexandre
Gayat, Etienne
Resche-Rigon, Matthieu
Rabuel, Christophe
Rezlan, Eva
Lukascewicz, Anne-Claire
Madadaki, Catharina
Pirracchio, Romain
Schurando, Patrick
Morel, Olivier
Fargeaudou, Yann
Payen, Didier
author_sort Heyer, Laurent
collection PubMed
description INTRODUCTION: Cardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage. METHODS: Tissue haemoglobin oxygen saturation of thenar eminence muscle (StO(2)) was measured via near-infrared spectroscopy technology. Two sets of StO(2 )parameters (both isolated baseline and during forearm ischaemia-reperfusion tests) were collected at two time points: upon intensive care unit admission and prior to intensive care unit discharge. Comparisons were performed using Wilcoxon paired tests, and univariate associations were assessed using logistic regression model and Wald tests. RESULTS: The 42 studied parturients, admitted for post-partum haemorrhage, had clinical and biological signs of severe blood loss. Initial cardiac troponin I was increased in 24/42 parturients (0.43 ± 0.60 μrg/l). All measured parameters of muscular haemoglobin oxygen saturation, including S(recovery), were also altered at admission and improved together with improved haemodynamics, when bleeding was controlled. Multivariate analysis showed that muscular S(recovery )<3%/second at admission was strongly associated with increased cardiac troponin. CONCLUSIONS: Our study confirmed the high incidence of increased cardiac troponin, and demonstrated the simultaneous impairment in the reserve of oxygen delivery to peripheral muscles in parturients admitted for severe post-partum haemorrhage.
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spelling pubmed-27861102009-12-02 Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage Heyer, Laurent Mebazaa, Alexandre Gayat, Etienne Resche-Rigon, Matthieu Rabuel, Christophe Rezlan, Eva Lukascewicz, Anne-Claire Madadaki, Catharina Pirracchio, Romain Schurando, Patrick Morel, Olivier Fargeaudou, Yann Payen, Didier Crit Care Research INTRODUCTION: Cardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage. METHODS: Tissue haemoglobin oxygen saturation of thenar eminence muscle (StO(2)) was measured via near-infrared spectroscopy technology. Two sets of StO(2 )parameters (both isolated baseline and during forearm ischaemia-reperfusion tests) were collected at two time points: upon intensive care unit admission and prior to intensive care unit discharge. Comparisons were performed using Wilcoxon paired tests, and univariate associations were assessed using logistic regression model and Wald tests. RESULTS: The 42 studied parturients, admitted for post-partum haemorrhage, had clinical and biological signs of severe blood loss. Initial cardiac troponin I was increased in 24/42 parturients (0.43 ± 0.60 μrg/l). All measured parameters of muscular haemoglobin oxygen saturation, including S(recovery), were also altered at admission and improved together with improved haemodynamics, when bleeding was controlled. Multivariate analysis showed that muscular S(recovery )<3%/second at admission was strongly associated with increased cardiac troponin. CONCLUSIONS: Our study confirmed the high incidence of increased cardiac troponin, and demonstrated the simultaneous impairment in the reserve of oxygen delivery to peripheral muscles in parturients admitted for severe post-partum haemorrhage. BioMed Central 2009 2009-11-30 /pmc/articles/PMC2786110/ /pubmed/19951392 http://dx.doi.org/10.1186/cc8006 Text en Copyright ©2009 BioMed Central Ltd
spellingShingle Research
Heyer, Laurent
Mebazaa, Alexandre
Gayat, Etienne
Resche-Rigon, Matthieu
Rabuel, Christophe
Rezlan, Eva
Lukascewicz, Anne-Claire
Madadaki, Catharina
Pirracchio, Romain
Schurando, Patrick
Morel, Olivier
Fargeaudou, Yann
Payen, Didier
Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title_full Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title_fullStr Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title_full_unstemmed Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title_short Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
title_sort cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786110/
https://www.ncbi.nlm.nih.gov/pubmed/19951392
http://dx.doi.org/10.1186/cc8006
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