Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis

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[Image: see text] Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite hal...

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Detalles Bibliográficos
Autores principales: Mann, Francis M., Xu, Meimei, Chen, Xiaoming, Fulton, D. Bruce, Russell, David G., Peters, Reuben J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787244/
https://www.ncbi.nlm.nih.gov/pubmed/19583202
http://dx.doi.org/10.1021/ja9019287
Descripción
Sumario:[Image: see text] Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.

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