Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis

Mostrar otras versiones (1)

[Image: see text] Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite hal...

Descripción completa

Detalles Bibliográficos
Autores principales: Mann, Francis M., Xu, Meimei, Chen, Xiaoming, Fulton, D. Bruce, Russell, David G., Peters, Reuben J.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2009
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787244/
https://www.ncbi.nlm.nih.gov/pubmed/19583202
http://dx.doi.org/10.1021/ja9019287
_version_ 1782174891323162624
author Mann, Francis M.
Xu, Meimei
Chen, Xiaoming
Fulton, D. Bruce
Russell, David G.
Peters, Reuben J.
author_facet Mann, Francis M.
Xu, Meimei
Chen, Xiaoming
Fulton, D. Bruce
Russell, David G.
Peters, Reuben J.
author_sort Mann, Francis M.
collection PubMed
description [Image: see text] Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.
format Text
id pubmed-2787244
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-27872442009-12-02 Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis Mann, Francis M. Xu, Meimei Chen, Xiaoming Fulton, D. Bruce Russell, David G. Peters, Reuben J. J Am Chem Soc [Image: see text] Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection. American Chemical Society 2009-07-07 2009-12-09 /pmc/articles/PMC2787244/ /pubmed/19583202 http://dx.doi.org/10.1021/ja9019287 Text en Copyright © 2009 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Mann, Francis M.
Xu, Meimei
Chen, Xiaoming
Fulton, D. Bruce
Russell, David G.
Peters, Reuben J.
Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title_full Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title_fullStr Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title_full_unstemmed Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title_short Edaxadiene: A New Bioactive Diterpene from Mycobacterium tuberculosis
title_sort edaxadiene: a new bioactive diterpene from mycobacterium tuberculosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787244/
https://www.ncbi.nlm.nih.gov/pubmed/19583202
http://dx.doi.org/10.1021/ja9019287
work_keys_str_mv AT mannfrancism edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis
AT xumeimei edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis
AT chenxiaoming edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis
AT fultondbruce edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis
AT russelldavidg edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis
AT petersreubenj edaxadieneanewbioactivediterpenefrommycobacteriumtuberculosis

Ejemplares similares