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Suppressive effect of secretory phospholipase A(2 )inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

INTRODUCTION: Secretory phospholipase A(2 )(sPLA(2)) and matrix metalloproteinase (MMP) inhibitors are potent modulators of inflammation with therapeutic potential, but have limited efficacy in rheumatoid arthritis (RA). The objective of this study was to understand the inhibitory mechanism of phosp...

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Detalles Bibliográficos
Autores principales:	Thwin, Maung-Maung, Douni, Eleni, Arjunan, Pachiappan, Kollias, George, Kumar, Prem V, Gopalakrishnakone, Ponnampalam
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787297/ https://www.ncbi.nlm.nih.gov/pubmed/19765281 http://dx.doi.org/10.1186/ar2810

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