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Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

BACKGROUND: Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cerv...

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Autores principales: Chatterjee, Koushik, Engelmark, Malin, Gyllensten, Ulf, Dandara, Collet, Merwe, Lize van der, Galal, Ushma, Hoffman, Margaret, Williamson, Anna-Lise
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787520/
https://www.ncbi.nlm.nih.gov/pubmed/19941645
http://dx.doi.org/10.1186/1756-0500-2-238
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author Chatterjee, Koushik
Engelmark, Malin
Gyllensten, Ulf
Dandara, Collet
Merwe, Lize van der
Galal, Ushma
Hoffman, Margaret
Williamson, Anna-Lise
author_facet Chatterjee, Koushik
Engelmark, Malin
Gyllensten, Ulf
Dandara, Collet
Merwe, Lize van der
Galal, Ushma
Hoffman, Margaret
Williamson, Anna-Lise
author_sort Chatterjee, Koushik
collection PubMed
description BACKGROUND: Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women. FINDINGS: Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. CONCLUSION: This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations.
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spelling pubmed-27875202009-12-03 Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans Chatterjee, Koushik Engelmark, Malin Gyllensten, Ulf Dandara, Collet Merwe, Lize van der Galal, Ushma Hoffman, Margaret Williamson, Anna-Lise BMC Res Notes Short Report BACKGROUND: Cervical cancer is one of the most important cancers in African women. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. This study investigated whether these polymorphisms are associated with cervical cancer or human papillomavirus (HPV) infection in South African women. FINDINGS: Participants were 447 women with invasive cervical cancer (106 black African and 341 women of mixed-ancestry) and 424 healthy women controls, matched by age, (101 black African and 323 women of mixed-ancestry) and domicile (rural or urban). Two polymorphisms in Fas gene (FasR-1377G/A, FasR-670A/G) and one in FasL gene (FasL844T/C) were genotyped by TaqMan. None of the polymorphisms, or the Fas haplotypes, showed a significant association with cervical cancer. There was also no association with HPV infection in the control group. However, on analysis of the control group, highly significant allele, genotype and haplotype differences were found between the two ethnic groups. There were generally low frequencies of FasR-1377A alleles, FasR-670A alleles and FasL-844C alleles in black women compared to the women of mixed-ancestry. CONCLUSION: This is the first study on the role of Fas and FasL polymorphisms in cervical cancer in African populations. Our results suggest that these SNPs are not associated with cervical cancer in these populations. The allele frequencies of the three SNPs differed markedly between the indigenous African black and mixed-ancestry populations. BioMed Central 2009-11-26 /pmc/articles/PMC2787520/ /pubmed/19941645 http://dx.doi.org/10.1186/1756-0500-2-238 Text en Copyright ©2009 Williamson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Chatterjee, Koushik
Engelmark, Malin
Gyllensten, Ulf
Dandara, Collet
Merwe, Lize van der
Galal, Ushma
Hoffman, Margaret
Williamson, Anna-Lise
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title_full Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title_fullStr Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title_full_unstemmed Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title_short Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans
title_sort fas and fasl gene polymorphisms are not associated with cervical cancer but differ among black and mixed-ancestry south africans
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787520/
https://www.ncbi.nlm.nih.gov/pubmed/19941645
http://dx.doi.org/10.1186/1756-0500-2-238
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