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Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
We performed a genome-wide association study (GWAS) in 1,713 Caucasian patients with Parkinson’s disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, two strong association signals were observed: in the α-synuclein gene(SNCA) (rs2736990, OR=1.23, p=2.24×10(−16)) and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787725/ https://www.ncbi.nlm.nih.gov/pubmed/19915575 http://dx.doi.org/10.1038/ng.487 |
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| author | Simon-Sanchez, Javier Schulte, Claudia Bras, Jose M Sharma, Manu Gibbs, J Raphael Berg, Daniela Paisan-Ruiz, Coro Lichtner, Peter Scholz, Sonja W Hernandez, Dena G Kruger, Rejko Federoff, Monica Klein, Christine Goate, Alison Perlmutter, Joel Bonin, Michael Nalls, Michael A Illig, Thomas Gieger, Christian Houlden, Henry Steffens, Michael Okun, Michael S. Cookson, Mark Foote, Kelly D Fernandez, Hubert H Traynor, Bryan J. Schreiber, Stefan Arepalli, Sampath Zonozi, Ryan Gwinn, Katrina van der Brug, Marcel Lopez, Grisel Chanock, Stephen J Schatzkin, Arthur Park, Yikyung Hollenbeck, Albert Gao, Jianjun Huang, Xuemei Wood, Nick W Lorenz, Delia Deuschl, Gunther Chen, Honglei Riess, Olaf Hardy, John A Singleton, Andrew B Gasser, Thomas |
| author_facet | Simon-Sanchez, Javier Schulte, Claudia Bras, Jose M Sharma, Manu Gibbs, J Raphael Berg, Daniela Paisan-Ruiz, Coro Lichtner, Peter Scholz, Sonja W Hernandez, Dena G Kruger, Rejko Federoff, Monica Klein, Christine Goate, Alison Perlmutter, Joel Bonin, Michael Nalls, Michael A Illig, Thomas Gieger, Christian Houlden, Henry Steffens, Michael Okun, Michael S. Cookson, Mark Foote, Kelly D Fernandez, Hubert H Traynor, Bryan J. Schreiber, Stefan Arepalli, Sampath Zonozi, Ryan Gwinn, Katrina van der Brug, Marcel Lopez, Grisel Chanock, Stephen J Schatzkin, Arthur Park, Yikyung Hollenbeck, Albert Gao, Jianjun Huang, Xuemei Wood, Nick W Lorenz, Delia Deuschl, Gunther Chen, Honglei Riess, Olaf Hardy, John A Singleton, Andrew B Gasser, Thomas |
| author_sort | Simon-Sanchez, Javier |
| collection | PubMed |
| description | We performed a genome-wide association study (GWAS) in 1,713 Caucasian patients with Parkinson’s disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, two strong association signals were observed: in the α-synuclein gene(SNCA) (rs2736990, OR=1.23, p=2.24×10(−16)) and at the MAPT locus (rs393152, OR=0.77, p=1.95×10(−16)). We exchanged data with colleagues performing a GWAS in Asian PD cases. Association at SNCA was replicated in the Asian GWAS1, confirming this as a major risk locus across populations. We were able to replicate the effect of a novel locus detected in the Asian cohort (PARK16, rs823128, OR=0.66, p=7.29×10(−8)) and provide evidence supporting the role of common variability around LRRK2 in modulating risk for PD (rs1491923, OR=1.14, p=1.55×10(−5)). These data demonstrate an unequivocal role for common genetic variability in the etiology of typical PD and suggest population specific genetic heterogeneity in this disease. |
| format | Text |
| id | pubmed-2787725 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27877252010-06-01 Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease Simon-Sanchez, Javier Schulte, Claudia Bras, Jose M Sharma, Manu Gibbs, J Raphael Berg, Daniela Paisan-Ruiz, Coro Lichtner, Peter Scholz, Sonja W Hernandez, Dena G Kruger, Rejko Federoff, Monica Klein, Christine Goate, Alison Perlmutter, Joel Bonin, Michael Nalls, Michael A Illig, Thomas Gieger, Christian Houlden, Henry Steffens, Michael Okun, Michael S. Cookson, Mark Foote, Kelly D Fernandez, Hubert H Traynor, Bryan J. Schreiber, Stefan Arepalli, Sampath Zonozi, Ryan Gwinn, Katrina van der Brug, Marcel Lopez, Grisel Chanock, Stephen J Schatzkin, Arthur Park, Yikyung Hollenbeck, Albert Gao, Jianjun Huang, Xuemei Wood, Nick W Lorenz, Delia Deuschl, Gunther Chen, Honglei Riess, Olaf Hardy, John A Singleton, Andrew B Gasser, Thomas Nat Genet Article We performed a genome-wide association study (GWAS) in 1,713 Caucasian patients with Parkinson’s disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, two strong association signals were observed: in the α-synuclein gene(SNCA) (rs2736990, OR=1.23, p=2.24×10(−16)) and at the MAPT locus (rs393152, OR=0.77, p=1.95×10(−16)). We exchanged data with colleagues performing a GWAS in Asian PD cases. Association at SNCA was replicated in the Asian GWAS1, confirming this as a major risk locus across populations. We were able to replicate the effect of a novel locus detected in the Asian cohort (PARK16, rs823128, OR=0.66, p=7.29×10(−8)) and provide evidence supporting the role of common variability around LRRK2 in modulating risk for PD (rs1491923, OR=1.14, p=1.55×10(−5)). These data demonstrate an unequivocal role for common genetic variability in the etiology of typical PD and suggest population specific genetic heterogeneity in this disease. 2009-11-15 2009-12 /pmc/articles/PMC2787725/ /pubmed/19915575 http://dx.doi.org/10.1038/ng.487 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Simon-Sanchez, Javier Schulte, Claudia Bras, Jose M Sharma, Manu Gibbs, J Raphael Berg, Daniela Paisan-Ruiz, Coro Lichtner, Peter Scholz, Sonja W Hernandez, Dena G Kruger, Rejko Federoff, Monica Klein, Christine Goate, Alison Perlmutter, Joel Bonin, Michael Nalls, Michael A Illig, Thomas Gieger, Christian Houlden, Henry Steffens, Michael Okun, Michael S. Cookson, Mark Foote, Kelly D Fernandez, Hubert H Traynor, Bryan J. Schreiber, Stefan Arepalli, Sampath Zonozi, Ryan Gwinn, Katrina van der Brug, Marcel Lopez, Grisel Chanock, Stephen J Schatzkin, Arthur Park, Yikyung Hollenbeck, Albert Gao, Jianjun Huang, Xuemei Wood, Nick W Lorenz, Delia Deuschl, Gunther Chen, Honglei Riess, Olaf Hardy, John A Singleton, Andrew B Gasser, Thomas Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title | Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title_full | Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title_fullStr | Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title_full_unstemmed | Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title_short | Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease |
| title_sort | genome-wide association study reveals genetic risk underlying parkinson’s disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787725/ https://www.ncbi.nlm.nih.gov/pubmed/19915575 http://dx.doi.org/10.1038/ng.487 |
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